Euro
USD
British Pound
NULL
Product Description
SA9 inhibits Hh pathway by interacting directly with Smo. It inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 19 µM). Induces the localization of Smo to cilia in ASZ1 cells, but not in IMCD3 cells. Also treatment of Ptch1-/- MEFs with SA9 suppresses the β-galactosidase activity (IC₅₀ = 1.0 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.
Smo Antagonist, SA9 inhibits Hh pathway by interacting directly with Smo. It inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 19 µM). Induces the localization of Smo to cilia in ASZ1 cells, but not in IMCD3 cells. Also treatment of Ptch1-/- MEFs with SA9 suppresses the β-galactosidase activity (IC₅₀ = 1.0 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.
Biovision | 2155 | Smo Antagonist, SA9 DataSheet
Alternate Name/Synonyms: 3-(3-(4-Fluorophenyl)-5-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl-N-(3-methylphenethyl)propanamide
Appearance: Crystalline solid
Formulation: N/A
CAS Number: N/A
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₇H₂₈ClN₅O₂
Molecular Weight: 490
Cell-Permeable?: Yes
Purity: ≥95% by NMR
Solubilities: DMSO
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A Hedgehog (Hh) signaling pathway antagonist
MDL Number: N/A
PubChem CID: 20880974
SMILES: C1CCC(=CC1)CCNC(=O)CCC2=NN=C3N2C4=CC=CC=C4C(=O)N3CC5=CC=C(C=C5)Cl
InChi: InChI=1S/C27H28ClN5O2/c28-21-12-10-20(11-13-21)18-32-26(35)22-8-4-5-9-23(22)33-24(30-31-27(32)33)14-15-25(34)29-17-16-19-6-2-1-3-7-19/h4-6,8-13H,1-3,7,14-18H2,(H,29,34)
InChi Key: YTDIPVZSLXYGNL-UHFFFAOYSA-N
