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Product Description
Cell-permeable. A specific and potent autophagy inhibitor in mammalian cells. It promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin specific peptidases, USP10 and USP13, that target the Beclin1 subunit of Vps34 complexes. Spautin-1 blocks the prosurvival autophagy pathway in cancer cells.
Spautin-1 is a specific and potent autophagy inhibitor in mammalian cells. It promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin specific peptidases, USP10 and USP13, that target the Beclin1 subunit of Vps34 complexes. Spautin-1 blocks the prosurvival autophagy pathway in cancer cells.
Biovision | 2037 | Spautin-1 DataSheet
Alternate Name/Synonyms: 6-Fluoro-N-(4-fluorobenzyl)quinozaline-4-amine
Appearance: White solid
Formulation: N/A
CAS Number: 1262888-28-7
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₅H₁₁F₂N₃
Molecular Weight: 271.26
Cell-Permeable?: No
Purity: ≥97% by HPLC
Solubilities: DMSO (~ 100 mM)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: An USP10 and USP13 inhibitor
MDL Number: N/A
PubChem CID: N/A
SMILES: N/A
InChi: N/A
InChi Key: N/A
