Product Description
H-151 is a potent antagonist of the signaling molecule STING in mouse and human cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. It reduces systemic cytokine response in mice treated with the STING agonist 10-carboxymethyl-9-acridanone and showed efficacy in Trex-/- mice.
STING antagonist, H-151 is a potent antagonist of the signaling molecule STING in mouse and human cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. It reduces systemic cytokine response in mice treated with the STING agonist 10-carboxymethyl-9-acridanone and showed efficacy in Trex-/- mice.
Biovision | B2395 | STING Antagonist, H-151 DataSheet
Alternate Name/Synonyms: H151, H-151, N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea
Appearance: Off-white solid
Formulation:
CAS Number: 941987-60-6
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₁₇H₁₇N₃O
Molecular Weight: 279.34
Cell-Permeable?: True
Purity: ≥98% by HPLC
Solubilities: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A STING antagonist
MDL Number:
PubChem CID: 7616033
SMILES: CCC1=CC=C(C=C1)NC(=O)NC2=CNC3=CC=CC=C32
InChi: InChI=1S/C17H17N3O/c1-2-12-7-9-13(10-8-12)19-17(21)20-16-11-18-15-6-4-3-5-14(15)16/h3-11,18H,2H2,1H3,(H2,19,20,21)
InChi Key: UJZDIKVQFMCLBE-UHFFFAOYSA-N