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Product Description
A potent and selective inhibitor (IC₅₀ = 700 nM) of vascular endothelial growth factor receptor 2 (VEGFR 2) (also known as Flk1). Very weak inhibitor of PDGFR-kinase (IC₅₀ >50 µM), EGFR-kinase (IC₅₀ >100 µM)and HER-2 kinase (IC₅₀>100 µM). SU1498 has been shown to cause accumulation of phosphorylated ERK and inhibits its activity in vivo and in vitro by inhibition of ERK dephosphorylation.
SU 1498 is a potent and selective inhibitor (IC₅₀ = 700 nM) of vascular endothelial growth factor receptor 2 (VEGFR 2) (also known as Flk1). Very weak inhibitor of PDGFR-kinase (IC₅₀ >50 µM), EGFR-kinase (IC₅₀ >100 µM)and HER-2 kinase (IC₅₀>100 µM).
Biovision | 1836 | SU 1498 DataSheet
Alternate Name/Synonyms: Tyrphostin SU 1498; (E)-N-(3″-Phenylpropyl)-α-cyano-3′,5′-diisopropyl-4′-hydroxycinnamamide
Appearance: Yellow powder
Formulation: N/A
CAS Number: N/A
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₅H₃₀N₂O₂
Molecular Weight: 390.52
Cell-Permeable?: Yes
Purity: ≥98% by TLC
Solubilities: DMSO (~20 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A VEGFR2 inhibitor
MDL Number: MFCD03453026
PubChem CID: 5941539
SMILES: CC(C)C1=CC(=CC(=C1O)C(C)C)C=C(C#N)C(=O)NCCCC2=CC=CC=C2
InChi: InChI=1S/C25H30N2O2/c1-17(2)22-14-20(15-23(18(3)4)24(22)28)13-21(16-26)25(29)27-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-15,17-18,28H,8,11-12H2,1-4H3,(H,27,29)/b21-13+
InChi Key: JANPYFTYAGTSIN-FYJGNVAPSA-N
