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Product Description
SU-5416 is a potent tyrosine kinase inhibitor best known as an inhibitor of the vascular endothelial growth factor receptor (VEGFR-2; Flk-1/KDR). In addition to inhibiting VEGFR-2 (IC₅₀ = 1 μM), SU-5416 also inhibits PDGFR (IC₅₀ = 20 μM), c-Kit (IC₅₀ = 30 nM), RET (IC₅₀ = 170 nM), Flt-3 (IC₅₀ = 160 nM), ABL (IC₅₀ = 11 μM), and ALK (IC₅₀ = 1.2 μM).SU 5416 does not inhibit epidermal growth factor (EGFR) or fibroblast growth factor receptor (FGFR) tyrosine kinases (IC₅₀ > 100 μM). Acts as a suppressor of tumor vascularization, preventing the growth of multiple tumor types.
SU-5416 is a potent tyrosine kinase inhibitor best known as an inhibitor of the vascular endothelial growth factor receptor (VEGFR-2; Flk-1/KDR). In addition to inhibiting VEGFR-2 (IC₅₀ = 1 μM), SU-5416 also inhibits PDGFR (IC₅₀ = 20 μM), c-Kit (IC₅₀ = 30 nM), RET (IC₅₀ = 170 nM), Flt-3 (IC₅₀ = 160 nM), ABL (IC₅₀ = 11 μM), and ALK (IC₅₀ = 1.2 μM).SU 5416 does not inhibit epidermal growth factor (EGFR) or fibroblast growth factor receptor (FGFR) tyrosine kinases (IC₅₀ > 100 μM).
Biovision | 9491 | SU-5416 DataSheet
Alternate Name/Synonyms: 3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one; Semaxinib
Appearance: Orange solid
Formulation: N/A
CAS Number: 204005-46-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₁₅H₁₄N₂O
Molecular Weight: 238.28
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>20 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent VEGFR kinase inhibitor
MDL Number: MFCD01940922
PubChem CID: 5329098
SMILES: CC1=CC(=C(N1)C=C2C3=CC=CC=C3NC2=O)C
InChi: InChI=1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8-
InChi Key: WUWDLXZGHZSWQZ-WQLSENKSSA-N
