Product Description
Tautomycin is a potent protein phosphatase inhibitor that inhibits PP1 completely at 3 nM and PP2 at 30 nM. Acts as a weak inhibitor of PP2B and does not inhibit PP2C. Its cell permeability and unique inhibitory profile makes tautomycin a useful tool for identifying phosphatase subtypes and physiological substrates for PP2 and PP2A.
Tautomycin is a potent protein phosphatase inhibitor that inhibits PP1 completely at 3 nM and PP2 at 30 nM. Acts as a weak inhibitor of PP2B and does not inhibit PP2C. Its cell permeability and unique inhibitory profile makes tautomycin a useful tool for identifying phosphatase subtypes and physiological substrates for PP2 and PP2A.
Biovision | B1237 | Tautomycin DataSheet
Alternate Name/Synonyms: [(3R,4R,5R,8S,9S,12R)-12-[(2S,3S,6R,8S,9R)-3,9-dimethyl-8-[(3S)-3-methyl-4-oxopentyl]-1,7-dioxaspiro[5.5]undecan-2-yl]-5,9-dihydroxy-4-methoxy-2,8-dimethyl-7-oxotridecan-3-yl] (3R)-3-hydroxy-3-(4-methyl-2,5-dioxofuran-3-yl)propanoate
Appearance: Colorless film
Formulation: N/A
CAS Number: 109946-35-2
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₄₁H₆₆O13
Molecular Weight: 766.95
Cell-Permeable?: Yes
Purity: ≥85% by HPLC
Solubilities: DMSO or EtOH
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent protein phosphatase inhibitor
MDL Number: N/A
PubChem CID: 440646
SMILES: CC1CCC2(CCC(C(O2)C(C)CCC(C(C)C(=O)CC(C(C(C(C)C)OC(=O)CC(C3=C(C(=O)OC3=O)C)O)OC)O)O)C)OC1CCC(C)C(=O)C
InChi: InChI=1S/C41H66O13/c1-21(2)36(51-34(47)20-31(45)35-27(8)39(48)52-40(35)49)38(50-10)32(46)19-30(44)26(7)29(43)13-11-24(5)37-25(6)16-18-41(54-37)17-15-23(4)33(53-41)14-12-22(3)28(9)42/h21-26,29,31-33,36-38,43,45-46H,11-20H2,1-10H3/t22-,23+,24+,25-,26-,29-,31+,32+,33-,36+,37-,38+,41+/m0/s1
InChi Key: RFCWHQNNCOJYTR-IRCAEPKSSA-N