Product Description
TC-S 7010 is a potent and selective inhibitor of Aurora kinase A (IC₅₀ = 3.4 nM). It displays1000-fold selectivity for Aurora kinase A over Aurora kinase B. Displays antiproliferative activity in HCT116 and HT29 cells (IC₅₀ values are 0.19 and 2.9 μM respectively).
TC-S 7010 is a potent and selective inhibitor of Aurora kinase A (IC₅₀ = 3.4 nM). It displays1000-fold selectivity for Aurora kinase A over Aurora kinase B. Displays antiproliferative activity in HCT116 and HT29 cells (IC₅₀ values are 0.19 and 2.9 μM respectively).
Biovision | B1203 | TC-S 7010 DataSheet
Alternate Name/Synonyms: N-(2-Chlorophenyl)-4-[[2-[[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]-benzamide
Appearance: White Solid
Formulation: N/A
CAS Number: 1158838-45-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₃₁H₃₁ClFN₇O₂
Molecular Weight: 588.07
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>50 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent and selective inhibitor of Aurora kinase A
MDL Number: N/A
PubChem CID: 44139710
SMILES: CCN1CCN(CC1)C(=O)CC2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4=CC=C(C=C4)C(=O)NC5=CC=CC=C5Cl)F
InChi: InChI=1S/C31H31ClFN7O2/c1-2-39-15-17-40(18-16-39)28(41)19-21-7-11-24(12-8-21)36-31-34-20-2
InChi Key: AKSIZPIFQAYJGF-UHFFFAOYSA-N