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Product Description
A p38 MAP kinase inhibitor. VX-702 dose-dependently inhibited the production of IL-6, IL-1β and TNFα (IC₅₀ = 59, 122 and 99 ng/ml, respectively). Pre-incubation of platelets with VX-702 (1 µM) completely or partially inhibited platelet agonist induced p38 activation (IC₅₀= 4 to 20 nM).
VX-702 is A p38 MAP kinase inhibitor. VX-702 dose-dependently inhibited the production of IL-6, IL-1β and TNFα (IC₅₀ = 59, 122 and 99 ng/ml, respectively).
Biovision | 1598 | VX-702 DataSheet
Alternate Name/Synonyms: 2-(2,4-Difluorophenyl)-6-(1-(2,6-difluorophenyl)ureido)nicotinamide
Appearance: White soild
Formulation: N/A
CAS Number: 745833-23-2
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₉H₁₂F₄N₄O₂
Molecular Weight: 404.32
Cell-Permeable?: Yes
Purity: ≥99% by HPLC
Solubilities: DMSO
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A p38 MAP kinase inhibitor
MDL Number: MFCD11616590
PubChem CID: 10341154
SMILES: C1=CC(=C(C(=C1)F)N(C2=NC(=C(C=C2)C(=O)N)C3=C(C=C(C=C3)F)F)C(=O)N)F
InChi: InChI=1S/C19H12F4N4O2/c20-9-4-5-10(14(23)8-9)16-11(18(24)28)6-7-15(26- 16)27(19(25)29)17-12(21)2-1-3-13(17)22/h1-8H,(H2,24,28)(H2,25,29)
InChi Key: FYSRKRZDBHOFAY-UHFFFAOYSA-N
