Product Description
WS6 is a novel Inducer of β cell proliferation. Inthe RIP-DTA mouse model of β cell ablation, WS6 normalizes blood glucose and induces concomitant increases in β cell proliferation and β cell number. Affinity pulldown and kinase profiling studies implicate ErbB3 binding protein-1 and the IκB kinase pathway in the mechanism of action of WS6.
WS6 is a novel Inducer of β cell proliferation. Inthe RIP-DTA mouse model of β cell ablation, WS6 normalizes blood glucose and induces concomitant increases in β cell proliferation and β cell number. Affinity pulldown and kinase profiling studies implicate ErbB3 binding protein-1 and the IκB kinase pathway in the mechanism of action of WS6.
Biovision | 2711 | WS6 DataSheet
Alternate Name/Synonyms: N-(6-(4-(2-((4-methylpiperazin-1yl)methyl)-3-(trifluoromethyl)phenyl)amino)-2-oxoethyl)phenoxy)pyrimidin-4-yl)cyclopropanecarboxamide
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 1421227-53-3
Structure Available?: Y
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₉H₃₁F₃N₆O₃
Molecular Weight: 568.59
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~ 20 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A cell proliferation inducer
MDL Number: N/A
PubChem CID: N/A
SMILES: O=C(NC1=CC=C(CN2CCN(C)CC2)C(C(F)(F)F)=C1)CC3=CC=C(OC4=NC=NC(NC(C5CC5)=O)=C4)C=C3
InChi: InChI=1S/C29H31F3N6O3/c1-37-10-12-38(13-11-37)17-21-6-7-22(15-24(21)29(30,31)32)35-26(39)14-19-2-8-23(9-3-19)41-27-16-25(33-18-34-27)36-28(40)20-4-5-20/h2-3,6-9,15-16,18,20H,4-5,10-14,17H2,1H3,(H,35,39)(H,33,34,36,40)
InChi Key: FTODTDQFHDJWIQ-UHFFFAOYSA-N