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Product Description
XL-147 is an ATP-competitive, highly selective, and reversible pan-class I phosphoinositide 3-kinase (PI3K) inhibitor. It inhibits PI3K p110α, -β, -γ, and -δ isoforms, with IC₅₀ values of 48, 617, 10, and 260 nmol/L, respectively, measured in biochemical assays. XL-147 displays antitumor activity.
XL-147 is an ATP-competitive, highly selective, and reversible pan-class I phosphoinositide 3-kinase (PI3K) inhibitor. It inhibits PI3K p110α, -β, -γ, and -δ isoforms, with IC₅₀ values of 48, 617, 10, and 260 nmol/L, respectively, measured in biochemical assays. XL-147 displays antitumor activity.
Biovision | 9401 | XL-147 DataSheet
Alternate Name/Synonyms: N-[3-(2,1,3-benzothiadiazol-5-ylamino)quinoxalin-2-yl]-4-methylbenzenesulfonamide; SAR245408; Pilaralisib
Appearance: Off-white solid
Formulation: N/A
CAS Number: 956958-53-5
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₁H₁₆N₆O₂S₂
Molecular Weight: 448.52
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~ 3 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A phosphoinositide 3-kinase (PI3K) inhibitor
MDL Number: N/A
PubChem CID: 56599306
SMILES: CC(C)(C(=O)NC1=CC(=CC=C1)S(=O)(=O)NC2=NC3=CC=CC=C3N=C2NC4=C(C=CC(=C4)OC)Cl)N
InChi: InChI=1S/C25H25ClN6O4S/c1-25(2,27)24(33)28-15-7-6-8-17(13-15)37(34,35)32-23-22(29-19-9-4-5-10-20(19)30-23)31-21-14-16(36-3)11-12-18(21)26/h4-14H,27H2,1-3H3,(H,28,33)(H,29,31)(H,30,32)
InChi Key: QINPEPAQOBZPOF-UHFFFAOYSA-N
