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Product Description
A synthetic peptide that irreversibly inhibits activity of LEVD-dependent caspases (e.g., caspase-4). The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Z-LEVD-FMK is a cell-permeable, irreversible caspase-4 inhibitor.
Biovision | 1144 | Z-LEVD-FMK DataSheet
Alternate Name/Synonyms: Z-LEVD-FMK, Z-LEVD-fluoromethylketone, Caspase-4 Inhibitor (fluoromethylketone)
Appearance: Lyophilized solid
Formulation: N/A
CAS Number: N/A
Structure Available?: No
Peptide sequence: Z-Leu-Glu(OMe)-Val-Asp(OMe)-FMK
Salt Form: No
Molecular Formula: C₃₁H₄₅FN₄O₁₀
Molecular Weight: 652.7
Cell-Permeable?: Yes
Purity: Single spot by TLC
Solubilities: DMSO (20 mM)
Handling: Protect from light and moisture
Country of Origin: USA
Tag Line: A caspase-4 inhibitor
MDL Number: N/A
PubChem CID: 44135220
SMILES: CC(C)CC(C(=O)NC(CCC(=O)OC)C(=O)NC(C(C)C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1
InChi: InChI=1S/C31H45FN4O10/c1-18(2)14-23(35-31(43)46-17-20-10-8-7-9-11-20)29(41)33-21(12-13-25(38)44-5)28(40)36-27(19(3)4)30(42)34-22(24(37)16-32)15-26(39)45-6/h7-11,18-19,21-23,27H,12-17H2,1-6H3,(H,33,41)(H,34,42)(H,35,43)(H,36,40)
InChi Key: WGJLXPZGHLANRB-UHFFFAOYSA-N
