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Product Description
A synthetic peptide that irreversibly inhibits activity of caspase family proteases and blocks apoptosis. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor.
Biovision | 1140 | Z-VAD-FMK DataSheet
Alternate Name/Synonyms: Z-VAD-FMK, Z-VAD-fluoromethylketone, Caspase-Family Inhibitor (fluoromethylketone)
Appearance: Lyophilized solid
Formulation: N/A
CAS Number: 187389-52-2
Structure Available?: No
Peptide sequence: Z-Val-Ala-Asp(OMe)-FMK
Salt Form: No
Molecular Formula: C₂₂H₃₀N₃O₇F
Molecular Weight: 467.5
Cell-Permeable?: yes
Purity: Single spot by TLC
Solubilities: DMSO (20 mM)
Handling: Protect from light and moisture
Country of Origin: USA
Tag Line: A pan-caspase inhibitor
MDL Number: MFCD01074990
PubChem CID: 5737
SMILES: CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1
InChi: InChI=1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)
InChi Key: MIFGOLAMNLSLGH-UHFFFAOYSA-N
