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Product Description
The Activated Human Protein C was activated from homogeneous protein C by activation with purified alpha-thrombin. The alpha-thrombin is removed after activation. Complete activation is observed on SDS-PAGE. Protein C (PROC) is a vitamin K-dependent serine protease which regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. PROC is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form, which contains a serine protease domain, functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in the PROC gene are linked with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis. This protein is purified from fresh frozen human plasma using a combination of salt precipitations and column chromatography.
Biovision | 7683 | Activated Protein C Human Plasma DataSheet
Biomolecule/Target: Activated Protein C
Synonyms: Vitamin K-dependent protein C, Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV, PROC, PC, APC, PROC1, THPH3, THPH4.
Alternates names: Vitamin K-dependent protein C, Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV, PROC, PC, APC, PROC1, THPH3, THPH4.
Taglines: Regulates blood coagulation by inactivating factors Va and VIIIa
NCBI Gene ID #: 5624
NCBI Gene Symbol: PROC
Gene Source: Human
Accession #: P04070
Recombinant: No
Source: Human Plasma
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): N/A
Biological activity: Lot dependent
Results: Lot dependent
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 56 kDa
Concentration: N/A
Appearance: Liquid
Physical form description: In 20 mM Tris-HCl, 0.1 M NaCl, pH 7.4
Reconstitution Instructions: N/A
Amino acid sequence: N/A
