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Product Description
Alpha 2 Antiplasmin is a member of the Serpin superfamily and the primary physiological inhibitor of the serine protease plasmin, which is responsible for the dissolution of fibrin clots. In addition to plasmin, it is also an efficient inhibitor of trypsin and chymotrypsin. Liver and kidney are major sites of its production and other tissues such as muscle, intestine, central nervous system, and placenta also express its mRNA at a moderate level. The tissue expression pattern indicates that it is a key regulator of plasmin mediated proteolysis in these tissues. Alpha-Antiplasmin-deficiency is a rare coagulation disorder which allows unrestrained fibrinolytic activity. Individuals with this condition may receive therapeutic A2AP prior to surgery to prevent postoperative hemorrhaging.
Biovision | 7295 | Alpha 2 Antiplasmin Human Plasma DataSheet
Biomolecule/Target: SERPINF2
Synonyms: Alpha-2-plasmin inhibitor, SERPINF2, AAP, PLI
Alternates names: Alpha-2-plasmin inhibitor, SERPINF2, AAP, PLI
Taglines: Physiological inhibitor of the serine protease plasmin.
NCBI Gene ID #: 5345
NCBI Gene Symbol: SERPINF2
Gene Source: Human
Accession #: P08697
Recombinant: No
Source: Human Plasma
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): N/A
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 70 kDa
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from 20 mM Bis-Tris, pH 6.4, with 200 mM NaCl.
Reconstitution Instructions: In water or aqueous buffer
Amino acid sequence: N/A
