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Product Description
1,3Nacetylglucosaminyltransferase 6 (3GnT6) transfers N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to N-acetylgalactosamine (GalNAc). 3GnT6 is also known as the core 3 synthase, because it creates the core 3 oligosaccharide structure in the mucin-type O-glycan, GlcNAc13GalNAc1serine/threonine. Core 3 synthase is a type II transmembrane protein, and is localized to stomach, small intestine and colonic tissues. It has long been known that synthesis of the core 3 structure is down-regulated in colonic cancer cells and it has been shown that the expression of 3GnT6 is also down-regulated. Colonic cancer cells transfected with 3GnT6 have reduced metastatic potential compared to non-transfected cells, and when injected into mice show decreased tumor formation. Pancreatic cancer cells transfected with 3GnT6 show a similar phenotype, which has been attributed to the addition of core3 O-glycans to 21 integrin.
Biovision | P1221 | B3GNT6 soluble fragment Human Recombinant DataSheet
Biomolecule/Target: B3GNT6
Synonyms: Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N acetylglucosaminyltransferase, Core 3 synthase, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6, BGnT-6, Beta-1,3-Gn-T6
Alternates names: Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N acetylglucosaminyltransferase, Core 3 synthase, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6, BGnT-6, Beta-1,3-Gn-T6
Taglines: An important precursor in the biosynthesis of mucin-type glycoproteins
NCBI Gene ID #: 843
NCBI Gene Symbol: CASP10
Gene Source: Human
Accession #: Q92851
Recombinant: Yes
Source: Insect cells
Purity by SDS-PAGEs: 90%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): Measured by transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to 4-Nitrophenyl-N-acetylgalactosamine, as measured with a phosphatase-coupled assay.
Biological activity: Specific activity >100 pmol/min/ug
Results: >100 pmol/min/ug
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 50-55 kDa
Concentration: 100 ug/ml
Appearance: Liquid
Physical form description: Sterile filtered solution in 25 mM Tris pH 7.5 and 150 mM NaCl
Reconstitution Instructions: N/A
Amino acid sequence: N/A
