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Product Description
Calreticulin is involved in regulation of intracellular Ca2+ homoeostasis and ER Ca2+ capacity. It constitutes together with calnexin and ERp57 the calreticulin/calnexin cycle that is responsible for folding and quality control of newly synthesized glycoproteins. Calreticulin has been implicated to play a role in many biological systems, including functions inside and outside the ER, indicating that the protein is a multi-process molecule. Recently, Calreticulin was shown to enhance the merger of macrophages and tumor cells, increasing phagocytosis.
Biovision | 7570 | Calreticulin human recombinant DataSheet
Biomolecule/Target: Calreticulin
Synonyms: CRP55; Calregulin; Endoplasmic Reticulum Resident Protein 60; ERp60; grp60
Alternates names: Fibroblast growth factor 19
Taglines: Involved in regulation of intracellular Ca2+ homoeostasis and ER Ca2+ capacity
NCBI Gene ID #: 9965
NCBI Gene Symbol: FGF19
Gene Source: Human
Accession #: NM_005117
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: <0.1 EU/g by LAL method
Activity (Specifications/test method): N/A
Biological activity: Determined by a cell proliferation assay using balb/c 3T3 cells. The expected ED for this effect is 50-200 ng/ml.
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 21.8 kDa
Concentration: N/A
Appearance: Liquid
Physical form description: 0.2 m-filtered solution in 55 mM Tris-Cl, pH 8.2, containing 150 mM NaCl.
Reconstitution Instructions: Reconstitute in HO to a concentration of 0.1 to 1.0 µg/µl. This solution can then be diluted into other aqueous buffers
Amino acid sequence: N/A
