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Product Description
EGF Receptor (EGFR, ErbB1) is a transmembrane protein that exerts tyrosine kinase activity upon ligand induced activation. EGFR can be activated by binding EGF or at least six other structurally related protein ligands, including TGF, HBEGF, Betacellulin (BTC), Amphiregulin, Epiregulin, and Epigen. Upon activation, EGFR initiates a signaling cascade which includes dimerization and internalization, tyrosine phosphorylation, DNA synthesis of target genes, and, ultimately, cell proliferation. EGFR signaling plays a role in the growth and differentiation of normal cells, but elevated EGFR activity is correlated with the development and pathogenesis of certain cancers. Recombinant soluble human EGFR is a 621 amino acid glycoprotein comprising the extracellular domain of EGFR, and migrates at an apparent MW of 97.5 kDa by SDS-PAGE analysis under reducing conditions.
Biovision | 7135 | EGF Receptor human recombinant DataSheet
Biomolecule/Target: EGFR
Synonyms: ErbB1
Alternates names: Interferon 2b, IFNA, INFA2, MGC125764, MGC125765
Taglines: Initiates a signaling cascade
NCBI Gene ID #: 3440
NCBI Gene Symbol: IFNA2b
Gene Source: Human
Accession #: Q86UP4
Recombinant: Yes
Source: CHO cells
Purity by SDS-PAGEs: 98%
Assay: SDS-PAGE
Purity: N/A
Assay #2: HPLC
Endotoxin Level: < 0.1 ng/g of protein (<1EU/g).
Activity (Specifications/test method): N/A
Biological activity: The specific activity as determined in a viral resistance assay using bovine kidney MDBK cells was found to be 2.6 x 10 units/mg
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 19.3 kDa
Concentration: N/A
Appearance: Lyophilized powder
Physical form description: Sterile filtered through a 0.2 micron filter. Lyophilized from 10 mM Sodium Phosphate, pH 7.5.
Reconstitution Instructions: Reconstitute in HO to a concentration of 1 mg/ml. This solution can then be diluted into other aqueous buffers
Amino acid sequence: N/A
