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Product Description
Epiregulin is part of the EGF family. Epiregulin functions as a ligand of EGFR, as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors. Epiregulin is expressed mostly in the placenta and peripheral blood leukocytes and in specific carcinomas of the bladder, lung, kidney and colon. Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and Vascular smooth muscle cells. Epiregulin inhibits the growth of several tumor-derived epithelial cell lines. Human Epiregulin is initially synthesized as a glycosylated 19.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0 kDa mature secreted sequence. Recombinant human EREG produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 50 amino acids and having a molecular mass of 6 kDa.
Biovision | 4069 | Epiregulin EREG human recombinant DataSheet
Biomolecule/Target: Epiregulin
Synonyms: Epiregulin, EREG
Alternates names: GDF-8, MSTN, Growth Differentiation Factor 8, MSTN Muscle Hypertrophy
Taglines: A ligand of EGFR, and most members of the ERBB family
NCBI Gene ID #: 2660
NCBI Gene Symbol: GDF8
Gene Source: Human
Accession #: O14793
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 98%
Assay: SDS-PAGE
Purity: 97%
Assay #2: HPLC
Endotoxin Level: <0.1 ng/g
Activity (Specifications/test method): N/A
Biological activity: Determined by its ability to inhibit the proliferation of MPC-11 cells. The ED for this effect is <20 ng/ml.
Results: <2.0 ng/ml
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 24.8 kDa
Concentration: N/A
Appearance: Lyophilized protein
Physical form description: Sterile filtered and lyophilized from 0.5 mg/ml solution containing 20 mM PBS, pH 7.4 and 130 mM NaCl.
Reconstitution Instructions: It is recommended to reconstitute the lyophilized human Myostatin in sterile 20 mM acetic acid to a concentration of 0.1 to 1.0 mg/ml. This solution can then be diluted into other aqueous buffers.
Amino acid sequence: N/A
