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Product Description
Galectin 2, also known as Lgals2, belongs to the galectins family. Galectins are a family of soluble beta-galactoside-binding animal lectins that modulate cell-to-cell adhesion and cell-to-extracellular matrix (ECM) interactions and play a role in tumor progression, pre-mRNA splicing and apoptosis. Lgals2 is a monomeric or homodimeric prototype galectin that is expressed in hepatoma, stomach epithelial cells and in colorectal and neural tumors. It induces apoptosis in activated T cells and binds to the cytokine lymphotoxin-a (LTA) with possible implications in risk of myocardial infarction. Human and mouse Lgals2 share approximately 65% amino acid sequence similarity. Recombinant Mouse Lgals2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Biovision | P1046 | Galectin-2 mouse recombinant DataSheet
Biomolecule/Target: Lgals2
Synonyms: Lgals2, 2200008F12Rik, AI324147, Gal-2
Alternates names: Mammotropin, Luterotropic hormone, Lutetropin, Prlr, PRL, luteotropic hormone, LTH, PRLR, PRL-R, PRL R
Taglines: A protein involved tumor progression, pre-mRNA splicing and apoptosis.
NCBI Gene ID #: 256249
NCBI Gene Symbol: PRL
Gene Source: Mouse
Accession #: P06879
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): The ED50 for this effect is 20 ug/ml. Measured by its ability to agglutinate human red blood cells.
Biological activity: The ED determined by the dose-dependent stimulation of the proliferation of rat lymphoma, Nb2-11 cells was found to be in the range of 0.1-1.0 ng/ml.
Results: ED50 is 20 ug/ml.
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 22.5 kDa
Concentration: N/A
Appearance: Liquid
Physical form description: In 20 mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol, 1mM DTT
Reconstitution Instructions: Reconstitute in HO to a concentration of 1.0 mg/ml. This solution can then be diluted into other aqueous buffers
Amino acid sequence: N/A
