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Product Description
Polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) catalyzes the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the hydroxyl group of serine and threonine residues. Twenty GalNAc-T genes have been identified in humans and most have been shown to represent active GalNAc-Ts. All isoforms are type II transmembrane proteins, with different but partly overlapping substrate preferences. The GalNAc-Ts control the initiation of mucin-type O-linked glycosylation and determine the location and density of O-glycans in a protein. Addition of GalNAc to an unglycosylated Ser/Thr residue creates the Tn antigen GalNAc1-S/T, and subsequent addition of sialic acid by ST6GalNAc-I forms the cancer associated STn antigen. GalNAc-T3 is highly expressed in pancreas and testis, and weakly expressed in a few other organs such as placenta. The expression levels of GalNAc-T3 were found to be upregulated in highly differentiated types of adenocarcinoma cell lines as opposed to less differentiated types. Overexpression of GalNAc-T3 has also been found to promote pancreatic cancer cell growth. Mutations in GalNAc-T3 were found to be involved in familial tumoral calcinosis, which may be mediated through glycosylation of fibroblast growth factor 23, protecting it from proteolytic cleavage. GalNAc-T3 has a preference for mono- or diglycosylated substrates.
Biovision | P1216 | GalNAc-T3 soluble fragment Human Recombinant DataSheet
Biomolecule/Target: GALNT3
Synonyms: Polypeptide N-acetylgalactosaminyltransferase 3, Polypeptide GalNAc transferase 3, GaNTase 3
Alternates names: Polypeptide N-acetylgalactosaminyltransferase 3, Polypeptide GalNAc transferase 3, GaNTase 3
Taglines: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis
NCBI Gene ID #: 25444
NCBI Gene Symbol: FGF9
Gene Source: Human
Accession #: P36364
Recombinant: Yes
Source: Insect cells
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): Measured by transfer of N-acetylgalatosamine (GalNac) from UDP-Gal to the peptide EA2, as measured with a phosphatase-coupled assay.
Biological activity: Specific activity >500 pmol/min/ug
Results: >500 pmol/min/ug
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: N/A
Concentration: 466 ug/ml
Appearance: Liquid
Physical form description: Sterile filtered solution in 25 mM Tris pH7.5 and 150 mM NaCl
Reconstitution Instructions: N/A
Amino acid sequence: N/A
