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Product Description
Polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5) catalyzes the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the hydroxyl group of serine and threonine residues, and was first cloned from rat. Twenty GalNAc-T genes have been identified in humans and most have been shown to represent active GalNAc-Ts. All isoforms are type II transmembrane proteins, with different but partly overlapping substrate preferences. The GalNAc-Ts control the initiation of mucin-type O-linked glycosylation and determine the location and density of O-glycans in a protein. Addition of GalNAc to an unglycosylated Ser/Thr residue creates the Tn antigen GalNAc1-S/T, and subsequent addition of sialic acid by ST6GalNAc-I forms the cancer associated STn antigen. GalNAc-T5 expression pattern is highly regulated, and is most abundant in salivary glands. GalNAc-T5 has a preference for unglycosylated or monoglycosylated substrates.
Biovision | P1217 | GalNAc-T5 soluble fragment Human Recombinant DataSheet
Biomolecule/Target: GALNT5
Synonyms: Polypeptide N-acetylgalactosaminyltransferase 5, Polypeptide GalNAc transferase 5, GaNTase 5
Alternates names: Polypeptide N-acetylgalactosaminyltransferase 5, Polypeptide GalNAc transferase 5, GaNTase 5
Taglines: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis
NCBI Gene ID #: 25444
NCBI Gene Symbol: FGF-9
Gene Source: Human
Accession #: P36364
Recombinant: Yes
Source: Insect cells
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): Measured by transfer of N-acetylgalatosamine (GalNac) from UDP-Gal to the peptide EA2, as measured with a phosphatase-coupled assay.
Biological activity: Specific activity >500 pmol/min/ug
Results: >500 pmol/min/ug
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: N/A
Concentration: 477 ug/ml
Appearance: Liquid
Physical form description: Sterile filtered solution in 25 mM Tris pH 7.5 and 150 mM NaCl
Reconstitution Instructions: N/A
Amino acid sequence: N/A
