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Product Description
HB-EGF is an EGF related growth factor which signals via the EGF receptor, and stimulates the proliferation of SMC (smooth muscle cells), fibroblasts, epithelial cells and keratinocytes. HB-EGF is expressed in various cell types and tissues, including vascular endothelial cells and SMC, macrophages, skeletal muscle, keratinocytes and particular tumor cells. HB-EGFs ability to explicitly bind heparin and heparin sulfate proteoglycans is dissimilar from other EGF-like molecules, and might be related to the enhanced mitogenic activity, relative to EGF, that HB-EGF exerts on smooth muscle cells.
Biovision | 4267 | HB-EGF mouse recombinant DataSheet
Biomolecule/Target: HB-EGF
Synonyms: Heparin-binding EGF-like growth factor, DTR, HEGFL, diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor), DTSF, proheparin-binding epidermal growth factor-like growth factor.
Alternates names: IBP-1, IGF-Binding Protein 1, AFBP, PP12, IGF-BP25, hIGFBP-1, IGFBP-1.
Taglines: EGF like growth factor involved in cell proliferation
NCBI Gene ID #: 3484
NCBI Gene Symbol: IBP1
Gene Source: Mouse
Accession #: P08833
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 98%
Assay: SDS-PAGE
Purity: 95%
Assay #2: HPLC
Endotoxin Level: N/A
Activity (Specifications/test method): N/A
Biological activity: The ED as determined by its ability to inhibit IGF-I induced proliferation of NUC-1 cells is ~100 ng/ml.
Results: ~100 ng/ml
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 28.8 kDa
Concentration: N/A
Appearance: Lyophilized protein
Physical form description: Lyophilized with no additives
Reconstitution Instructions: Reconstitute in HO to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and store at 4°C for 1 week or 20°C for future use.
Amino acid sequence: N/A
