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Product Description
Hemocyanins are proteins that use copper binding sites to bind and transport oxygen in a variety of arthropods and mollusks. Hemocyanin is isolated from the hemolymph of the animals. Hemocyanin is one of the strongest antigens known. Hemocyanin has been in use as an immunological reagent for many years. It is used as a carrier protein for antibody production against antigens. Recent advances in immunology and the role immune system plays in diseases have opened a whole new era of product development activities aimed at developing novel therapeutics which is aimed at teaching the body's immune system to fight diseases like cancer, AIDS, etc. The approach involves the use of highly immunogenic molecule like the hemocyanin for non-specific immunostimulation (NSI) or active specific immunostimulation (ASI) using conjugate vaccines, wherein the tumor (disease) specific antigens are covalently bound to carrier protein like KLH and the product used in human clinical studies. Such products are termed vaccines. BioVisions KLH subunits powder has major advantages associated with it, in terms of flexibility of use, the choice of buffer in early developmental studies and avoidance of issues associated with reconstitution of dry powder. These subunits are highly pure and have low endotoxin content.
Biovision | 6287 | Hemocyanin-Keyhole Limpet KLH subunits solution DataSheet
Biomolecule/Target: N/A
Synonyms: KLH, keyhole limpett hemocyanin, hemocyanin, Megathura crenulata hemocyanin
Alternates names: KLH, keyhole limpett hemocyanin, hemocyanin, Megathura crenulata hemocyanin
Taglines: Pure KLH ideal for antibody purification and as a carrier protein and immunogen
NCBI Gene ID #: 12985
NCBI Gene Symbol: CSF3
Gene Source: Megathura crenulata
Accession #: P09920
Recombinant: No
Source: Megathura crenulata, Giant keyhole limpet
Purity by SDS-PAGEs: 98%
Assay: MPLC-SEC
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): N/A
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 350 and 390 kDa (Two main characteristic bands co-migrating with ferritin)
Concentration: 20 mg/ml
Appearance: Liquid
Physical form description: 20 mg/ml of clear dark blue liquid which may contain some particulate and fibers.
Reconstitution Instructions: N/A
Amino acid sequence: N/A
