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Product Description
B-cell activating factor (BAFF), also known as tumor necrosis factor ligand superfamily member 13B , TNFSF13B, BAFF, B Lymphocyte Stimulator (BLyS), cluster of differentiation 257 (CD257), DTL, TNF- and APOL-related leukocyte expressed ligand (TALL-1), THANK, TNFSF20, ZTNF4, and is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. It is expressed as transmembrane protein on various cell types including monocytes, dendritic cells and bone marrow stromal cells. BAFF is the natural ligand of three unusual tumor necrosis factor receptors named BAFF-R, TACI, and BCMA, all of which have differing binding affinities for it. These receptors are expressed mainly on mature B lymphocytes (TACI is also found on a subset of T-cells and BCMA on plasma cells). TACI binds worst since its affinity is higher for a protein similar to BAFF, called a proliferation-inducing ligand (APRIL). BCMA displays an intermediate binding phenotype and will work with either BAFF or APRIL to varying degrees. Signaling through BAFF-R and BCMA stimulates B lymphocytes to undergo proliferation and to counter apoptosis. All these ligands act as heterotrimers (i.e. three of the same molecule) interacting with heterotrimeric receptors, although BAFF has been known to be active as either a hetero- or homotrimer. BAFF acts as a potent B cell activator and has been shown to play an important role in the proliferation and differentiation of B cells.
Biovision | P1370 | Human CellExp BAFF Mouse Recombinant DataSheet
Biomolecule/Target: BAFF
Synonyms: TNFSF13B, BAFF, BLYS, CD257, DTL, TALL-1, TALL1, THANK, TNFSF20, ZTNF4
Alternates names: TNFSF13B, BAFF, BLYS, CD257, DTL, TALL-1, TALL1, THANK, TNFSF20, ZTNF4
Taglines: A potent B cell activator
NCBI Gene ID #: 116630
NCBI Gene Symbol: CSF2
Gene Source: Mouse
Accession #: P48750
Recombinant: Yes
Source: HEK 293 cells
Purity by SDS-PAGEs: 98%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: < 1.0 EU per 1 g of protein
Activity (Specifications/test method): Measured by its binding ability in a functional ELISA
Biological activity: Immobilized Mouse BAFF at 2 g/mL (100 L/well) can bind Mouse BAFFR, Fc Tag with a linear range of 0.4-3 ng/mL
Results: N/A
Binding Capacity: Immobilized Mouse BAFF at 2 g/mL (100 L/well) can bind Mouse BAFFR, Fc Tag with a linear range of 0.4-3 ng/mL
Unit Definition: N/A
Molecular Weight: 20.9 kDa
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH5.0. Normally trehalose is added as protectant before lyophilization.
Reconstitution Instructions: Reconstitute in sterile deionized water to a concentration of 100 µg/ml.
Amino acid sequence: N/A
