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Product Description
BAFF receptor (B-cell activating factor receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), is a membrane protein of the TNF receptor superfamily which recognizes BAFF. B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of BAFF in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.
Biovision | P1170 | Human CellExp BAFFR / TNFRSF13C Fc Tag Human Recombinant DataSheet
Biomolecule/Target: TNFRSF13C
Synonyms: BAFFR, TNFRSF13C, BAFF-R, BROMIX, CD268, CVID4, prolixin
Alternates names: Cytotoxic lymphocyte maturation factor 40 kDa subunit Short name=CLMF p40 IL-12 subunit p40 NK cell stimulatory factor chain 2
Taglines: Promotes the survival of mature B-cells and the B-cell response
NCBI Gene ID #: 3593
NCBI Gene Symbol: IL12
Gene Source: Human
Accession #: P29460
Recombinant: Yes
Source: HEK293 cells
Purity by SDS-PAGEs: 98%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: < 1.0 EU per/g
Activity (Specifications/test method): Measured by its binding ability in a functional ELISA.
Biological activity: N/A
Results: N/A
Binding Capacity: Immobilized Human BAFF, His Tag at 5 g/mL (100 L/well) can bind Human BAFFR, Fc Tag with a linear range of 2-31 ng/mL
Unit Definition: N/A
Molecular Weight: 40.0 kDa
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from 0.22 m filtered solution in PBS pH 7.4. Generally 5-8% Mannitol or Trehalose is added as a protectant before lyophilization.
Reconstitution Instructions: Reconstitute in 1X PBS, pH 7.2 to a concentration of 0.1-1 mg/ml. The solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or 20°C for future use.
Amino acid sequence: N/A
