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Product Description
Interleukin 3 receptor alpha (low affinity) (IL3RA), also known as CD123 (Cluster of Differentiation 123) is a 70-kD glycoprotein member of the hematopoietin receptor superfamily. This protein associates with a beta subunit common to the receptors for IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF) to form a high-affinity receptor for IL-3. The interleukin-3 receptor chain (CD123) has been identified as a potential immunotherapeutic target because it is overexpressed in AML compared with normal hematopoietic stem cells.
Biovision | P1368 | Human CellExp CD123 / IL-3 R alpha Human Recombinant DataSheet
Biomolecule/Target: IL3RA
Synonyms: IL3R, IL3RA, IL-3Ra, IL-3R-alpha, IL3RAY, IL3RX, IL3RY, CD123 antigen, CD123, hIL3Ra, hIL-3Ra, MGC34174, IL-3 R alpha
Alternates names: PIGF, PGF, PLGF 1, Placenta Growth Factor-1
Taglines: Receptor for interleukin-3
NCBI Gene ID #: 5228
NCBI Gene Symbol: PGF
Gene Source: Human
Accession #: AAD30179
Recombinant: Yes
Source: HEK 293 cells
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: >95%
Assay #2: N/A
Endotoxin Level: <1 EU/g by LAL method
Activity (Specifications/test method): N/A
Biological activity: Determined by its ability to chemoattract human monocytes of using a concentration range of 0.5-10 ng/ml.
Results: 0.5-10 ng/ml
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 29.7 kDa
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH 7.4. Normally trehalose is added as protectant before lyophilization.
Reconstitution Instructions: Reconstitute the protein in sterile 20 mM acetic acid to a concentration of 0.1-1.0 g/l. The solution can then be diluted into other aqueous buffer
Amino acid sequence: N/A
