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Product Description
Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation.
Biovision | P1366 | Human CellExp CD27 Ligand/ CD70 Fc Tag Human Recombinant DataSheet
Biomolecule/Target: CD70
Synonyms: CD70, CD27LG, TNFSF7, TNFSF7G, CD27L
Alternates names: INT-1, Proto-oncogene Int-1 homolog
Taglines: Cytokine that binds to CD27 and plays role in T-cell activation.
NCBI Gene ID #: 7471
NCBI Gene Symbol: WNT1
Gene Source: Human
Accession #: P04628
Recombinant: Yes
Source: HEK 293 cells
Purity by SDS-PAGEs: 98%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: <1 EU/g by LAL method
Activity (Specifications/test method): Measured by its binding ability in a functional ELISA
Biological activity: The ED was determined by its ability to enhance BMP-2 induced alkaline phosphatase production by murine ATDC5 cells. The expected ED for this effect is 1.5 - 2.5 ng/ml in the presence of 200 ng/ml of human BMP-2.
Results: 1.5 - 2.5 ng/m
Binding Capacity: Immobilized Human CD27, Mouse IgG2a Fc Tag at 2 g/mL (100 L/well) can bind Human CD27 Ligand, Fc Tag with a linear range of 0.4-13 ng/mL.
Unit Definition: N/A
Molecular Weight: 38.4 kDa
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from PBS
Reconstitution Instructions: Reconstitute in HO to a concentration of 0.1-1.0 µg/µl. The solution can then be diluted into other aqueous buffers
Amino acid sequence: N/A
