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Product Description
Colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR, FIM2, FMS, and is a member of the type III subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation. Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.
Biovision | 7505 | Human CellExp CSF1R / CD115 / CD6 human recombinant DataSheet
Biomolecule/Target: CSF1R / CD115 / CD6
Synonyms: CD6, CD-6, Cluster of Differentiation 6, FLJ44171, TP120
Alternates names: Thrombospondin-1, THBS1, TSP, TSP1, THBS, THBS-1
Taglines: 98% pure, active, human cell expressed, human recombinant CSF1R / CD115 / CD6, which mediates all effects of cytokine CSF-1
NCBI Gene ID #: 7057
NCBI Gene Symbol: TSP1
Gene Source: Human
Accession #: P07996
Recombinant: Yes
Source: HEK293 cells
Purity by SDS-PAGEs: 98%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: <1 EU/g by LAL method
Activity (Specifications/test method): N/A
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 181 kDa in reducing Gel
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Reconstitution Instructions: Reconstitute with water at the concentration 0.1 mg/ml.
Amino acid sequence: N/A
