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Product Description
Interleukin-17 is a proinflammatory cytokine produced by activated T cells. IL-17 regulates the activities of NF-kappa B and mitogen-activated protein kinases. IL17 can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The original described IL-17 protein, now known as IL-17A, was identified from a CD4+ T cells DNA library. IL-17 can be induced from primary peripheral blood CD4+ T cells upon stimulation. Supernatant from cells transfected with IL-17 induced IL-16 and IL-18 production and enhanced the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts.
Biovision | 6468 | Human CellExp IL-17A Human Recombinant DataSheet
Biomolecule/Target: N/A
Synonyms: Human Cellexp Human Recombinant IL-17A
Alternates names: Acrp-30, GBP-28, Apm-1, 30 kDa adipocyte complement-related protein, Adipocyte complement-related 30 kDa protein, Adipocyte, C1q and collagen domain-containing protein, Adipose most abundant gene transcript 1 protein, Gelatin-binding protein
Taglines: A proinflammatory cytokine produced by activated T cells
NCBI Gene ID #: 9370
NCBI Gene Symbol: ADIPOQ
Gene Source: Human
Accession #: NP_004788
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 90%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: < 1.0 EU per 1 g of protein
Activity (Specifications/test method): N/A
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 30 kDa
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized in 10 mM Tris, pH 7.4 and 250 mM NaCl.
Reconstitution Instructions: Recontitute in water containing at least 0.1% BSA to a concentration of 0.1-1.0 mg/ml. This stock solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or 20°C for future use.
Amino acid sequence: N/A
