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Product Description
Interleukin-13 receptor subunit alpha-2, also known as IL13R2, IL13Ra2 cluster of differentiation 213A2, CD213A2, CT19, IL-13R, IL13BP, and is a membrane bound protein that in humans is encoded by the IL13RA2 gene. IL13R2 is closely related to IL13R1, a subunit of the interleukin-13 receptor complex. This protein binds IL13 with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator. It is, however able to regulate the effects of both IL13 and IL4, despite the fact it is unable to bind directly to the latter. It is also reported to play a role in the internalization of IL13. IL13R2 is a component of the cell surface receptors, however, the majority exists in intracellular pools and in soluble form, and thus plays an opposite role as a potent IL13 antagonist compared with IL13R1. It also functions as an inhibitor of IL4-dependent pathway probably through the physical interaction between the short intracellular domain of and cytoplasmic domain of IL13R2 and the IL4R chain. In spite of the failed STAT signaling function, IL13R2 dose induce TGF-beta production and fibrosis. Additionally, IL13R2has been reported to be abundantly and specifically overexpressed in glioblastoma multiforme.
Biovision | 7489 | Human CellExp IL13RA2/CD213 human recombinant DataSheet
Biomolecule/Target: IL13RA2/CD213
Synonyms: IL13RA2, IL-13RA2, CD213A2, CD2132, CT19, CT-19, IL-13R, IL13BP, IL-13BP, IL-13R2
Alternates names: Acrp-30, GBP-28, Apm-1, 30 kDa adipocyte complement-related protein, Adipocyte complement-related 30 kDa protein, Adipocyte, C1q and collagen domain-containing protein, Adipose most abundant gene transcript 1 protein, Gelatin-binding protein
Taglines: Regulates the effects of both IL13 and IL4.
NCBI Gene ID #: 9370
NCBI Gene Symbol: ADIPOQ
Gene Source: Human
Accession #: NP_004788
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 90%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: <1 EU/g by LAL method
Activity (Specifications/test method): N/A
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 30 kDa
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from 0.22 m filtered solution in 50 mM Tris, 100 mM glycine, pH 7.0. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Reconstitution Instructions: Recontitute in water containing at least 0.1% BSA to a concentration of 0.1-1.0 mg/ml. This stock solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or 20°C for future use.
Amino acid sequence: N/A
