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Product Description
Insulin receptor (INSR) is also known as CD antigen CD220, which can be cleaved into the following 2 chains: Insulin receptor subunit alpha and Insulin receptor subunit beta. INSR is a tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains carry the insulin-binding regions, while the beta chains carry the kinase domain. Forms a hybrid receptor with IGF1R, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short of INSR has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, INSR binds IGF1.
Biovision | P1377 | Human CellExp Insulin R / CD220 Human Recombinant DataSheet
Biomolecule/Target: Insulin R / CD220
Synonyms: INSR, Insulin receptor, IR, CD220
Alternates names: Nicotinamide phosphoribosyltransferase, Pre-B-cell colony-enhancing factor 1 homolog, NAmPRTase, Nampt, PBEF
Taglines: Receptor tyrosine kinase which mediates the pleiotropic actions of insulin.
NCBI Gene ID #: 297508
NCBI Gene Symbol: NAMPT
Gene Source: Rat
Accession #: Q80Z29
Recombinant: TRUE
Source: E. coli
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: Less than 1.0 EU per g by the LAL method.
Activity (Specifications/test method):
Biological activity: Amino acids 1 to 491 (per UniProt Q80Z29)
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 53.0 kDa
Concentration: N/A
Appearance: Lyophilized powder
Physical form description: Lyophilized
Reconstitution Instructions: Reconstitute in PBS to the concentration of 0.1-1 mg/ml.
Amino acid sequence: Amino acids 1 to 491 (per UniProt Q80Z29)
