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Product Description
Integrin alpha V beta 5 (ITGAV & ITGB5 or ITGAVB5) is expressed on a wide variety of cell types including keratinocytes, fibroblasts, adhesive monocytes, embryonic stem cells, and select endothelium and epithelium. ITGAV & ITGB5 binds ligands containing an RGD motif, notably vitronectin. Growth factors that increase PKC activity, such as VEGF or TGF alpha, promote ITGAVB5-mediated angiogenesis while alpha V beta 3, which may be expressed in the same cell, responds to FGF-basic and TNF alpha. An inhibitor of both down regulates tumor angiogenesis. During lung inflammation, up regulation of ITGAVB5 on myofibroblasts or infiltrating lymphocytes may contribute to fibrosis by freeing TGF beta from latency.
Biovision | P1121 | Human CellExp Integrin alpha V beta 5 Heterodimer Human recombinant DataSheet
Biomolecule/Target: ITGAV, ITGB5
Synonyms: Integrin alpha V beta 5, ITGAVB5, ITGAV & ITGB5
Alternates names: Acetyl-CoA acetyltransferase cytosolic, Cytosolic acetoacetyl-CoA thiolase, ACAT2, Acetyl CoA transferase-like protein, ACAT-2, Sterol O-acyltransferase 2, Acyl-coenzyme A:cholesterol acyltransferase 2, Cholesterol acyltransferase 2
Taglines: N/A
NCBI Gene ID #: 39
NCBI Gene Symbol: THIC
Gene Source: Human
Accession #: Q9BWD1
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: < 1.0 EU per/g
Activity (Specifications/test method): N/A
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 41.3 kDa
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH7.4. Normally Trehalose is added as protectant before lyophilization.
Reconstitution Instructions: N/A
Amino acid sequence: N/A
