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Product Description
Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.
Biovision | P1011 | Human CellExp KLF4-TAT Human Recombinant DataSheet
Biomolecule/Target: KLF4-TAT
Synonyms: Krueppel-like factor 4, Epithelial zinc finger protein EZF, Gut-enriched krueppel-like factor, EZF, GKLF
Alternates names: VGR, VGR1, BMP-6, VG-1-related protein
Taglines: A transcription factor that act both as an activator and as a repressor.
NCBI Gene ID #: 654
NCBI Gene Symbol: BMP6
Gene Source: Human
Accession #: P22004
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 98%
Assay: SDS-PAGE
Purity: 90%
Assay #2: HPLC
Endotoxin Level: < 1 EU/g
Activity (Specifications/test method): N/A
Biological activity: BioVisions recombinant human BMP-6 is biologically active. The ED as determined by dose-dependent induction of alkaline phosphatase activity with C2C12 cells is in the range of 2-12 µg/ml.
Results: 2-12 µg/ml
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: monomer (15 kDa), dimer (30 kDa)
Concentration: N/A
Appearance: Dry powder
Physical form description: Lyophilized powder
Reconstitution Instructions: Reconstitute to a concentration of 0.1-1.0 mg/ml in sterile 20 mM acetic acid. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or 20°C for future use.
Amino acid sequence: N/A
