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Product Description
Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) is also known as CD85 antigen-like family member K (CD85K), Immunoglobulin-like transcript 3 (ILT-3), Leukocyte immunoglobulin-like receptor 5 (LIR-5), Monocyte inhibitory receptor HM18, which belongs to the leukocyte immunoglobulin-like receptor (LIR) family. LILRB4 / CD85K contains 2 Ig-like C2-type (immunoglobulin-like) domains. CD85K is detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. LILRB4 / CD85K is receptor for class I MHC antigens. CD85K recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles, involved in the down-regulation of the immune response and the development of tolerance. LILRB4 interferes with TNFRSF5-signaling and NF-kappa-B up-regulation and inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
Biovision | P1188 | Human CellExp LILRB4 / CD85k / ILT3 Mouse Recombinant DataSheet
Biomolecule/Target: LILRB4
Synonyms: LILRB4, ILT3, LIR5, CD85K, HM18
Alternates names: HL1, LFR, HL-1, INTL, ITLN, hIntL, omentin, FLJ20022, ITLN1
Taglines: Receptor for class I MHC antigens
NCBI Gene ID #: 55600
NCBI Gene Symbol: ITLN1
Gene Source: Human
Accession #: Q8WWA0
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 98%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: < 1.0 EU per/g
Activity (Specifications/test method): N/A
Biological activity: Not available at this time
Results: N/A
Binding Capacity: Immobilized Human ANGPTL7, His Tag at 5 g/mL (100 L/well) can bind Mouse LILRB4, Fc Tag with a linear range of 0.156-1.25 g/mL.
Unit Definition: N/A
Molecular Weight: 35.0 kDa
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from 0.22 m filtered solution in PBS pH 7.4. Generally 5-8% Mannitol or Trehalose is added as a protectant before lyophilization.
Reconstitution Instructions: Reconstitute in HO to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers
Amino acid sequence: N/A
