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Product Description
Leucine-rich repeat protein 32 (LRRC32), also known as GARP (glycoprotein A repetitions predominant). LRRC32 expression promotes the acquisition of a Treg phenotype including reduced cellular proliferation, reduced cytokine secretion, and the capacity to suppress the proliferation of naïve T cells. LRRC32 binds directly to the TGF-beta latency associated peptide (LAP) and tethers latent TGF-beta on the surface of activated Treg cells. The presentation of TGF-beta on Tregs contributes to their ability to suppress naïve T cell proliferation.
Biovision | P1207 | Human CellExp LRRC32 / GARP Fc Tag Human Recombinant DataSheet
Biomolecule/Target: LRRC32
Synonyms: GARP, Garpin, D11S833E, Glycoprotein A repetitions predominant
Alternates names: IDL
Taglines: Binds to TGF-beta to suppress naïve T cell proliferation.
NCBI Gene ID #: 4035
NCBI Gene Symbol: LRP1
Gene Source: N/A
Accession #: Q07954
Recombinant: Yes
Source: Human plasma
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: < 1.0 EU per/g
Activity (Specifications/test method): N/A
Biological activity: N/A
Results: N/A
Binding Capacity: Immobilized Latent TGFB1, N-His at 5 g/mL (100 L/well) can bind Human LRRC32, Fc Tag with a linear range of 0.039-2.5 g/mL.
Unit Definition: N/A
Molecular Weight: 5.0-10,000.0 kDa
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH7.4. Generally Mannitol or Trehalose is added as a protectant before lyophilization.
Reconstitution Instructions: N/A
Amino acid sequence: N/A
