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Product Description
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive pro-proteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. Thrombospondins, intervertebral disc proteins, regulate the effective levels of matrix metalloproteinases (MMPs) 2 and 9, which are key effectors of ECM remodeling. Matrix metalloproteinase-1 (MMP-1) also known as interstitial collagenase and fibroblast collagenase. MMP1 is expressed by fibroblasts, keratinocytes, endothelial cells, monocytes and macrophages. MMP-1 breaks down the interstitial collagens, types I, II, and III. MMP1 can degrade a broad range of substrates including types I, II, III, VII, VIII, and X collagens as well as casein, Gelatin, myelin basic protein, L Selectin, proTNF, IL1, IGFBP3, IGFBP5, pro MMP2 and pro MMP9.
Biovision | 7244 | Human CellExp MMP-1 human recombinant DataSheet
Biomolecule/Target: MMP-1
Synonyms: MMP1, CLG, CLGN
Alternates names: Retinol Binding Protein 4, RBP-4, RBP4, Plasma retinol-binding protein, PRBP, RBP.
Taglines: Involved in the breakdown of extracellular matrix
NCBI Gene ID #: 5950
NCBI Gene Symbol: RET4
Gene Source: Human
Accession #: P02753
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: HPLC
Endotoxin Level: < 0.1 ng/g of protein (<1EU/g).
Activity (Specifications/test method): N/A
Biological activity: Immune reactive in ELISA using monoclonal anti CD4 in gpl2O capture ELISA assays.
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 21.0 kDa
Concentration: N/A
Appearance: Lyophilized powder
Physical form description: Lyophilized from 0.22 m filtered solution in MES, NaCl, CaCl2 and Brij35. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
Reconstitution Instructions: N/A
Amino acid sequence: N/A
