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Product Description
Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF- family and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis.
Biovision | 6474 | Human CellExp Noggin Human Recombinant DataSheet
Biomolecule/Target: N/A
Synonyms: Human Cellexp Human Recombinant Noggin
Alternates names: SUMO3; SMT3A; SMT3H1; SUMO-3, SMT3 homolog 1, SUMO-2, Ubiquitin-like protein SMT3B
Taglines: An inhibitor of TGF- signal transduction
NCBI Gene ID #:
NCBI Gene Symbol: SUMO3
Gene Source: Human
Accession #:
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: < 1.0 EU per 1 g of protein
Activity (Specifications/test method): N/A
Biological activity: Typical in vitro concentrations for conjgate formation is 10-50 µM depending on conditions.
Results: 10-50 µM
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 11.6 kDa
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized in PBS.
Reconstitution Instructions: N/A
Amino acid sequence: N/A
