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Product Description
Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as Butyrophilin B7-DC, CD antigen CD273, which belongs to the immunoglobulin superfamily or BTN/MOG family. The expression of PD-L2 is up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL-4. PD-L2 Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PD-L2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
Biovision | P1087 | Human CellExp PD-L2 / B7-DC mouse recombinant DataSheet
Biomolecule/Target: PD-L2
Synonyms: PDL2, PD-L2, Butyrophilin B7-DC, CD273, PDCD1 ligand 2, PDCD1L2, PDCD1LG2
Alternates names: EPG, Epigen, PRO9904, ALGV3072, FLJ75542, EPGN, Epithelial mitogen,
Taglines: A protein involved in the costimulatory signal essential for T-cell proliferation.
NCBI Gene ID #: 255324
NCBI Gene Symbol: EPGN
Gene Source: Human
Accession #: Q6UW88
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 98%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: < 0.1 EU/g
Activity (Specifications/test method): N/A
Biological activity: Determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells. The expected ED for this effect is 150-300 ng/ml.
Results: 150-300 ng/ml
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 7.9 kDa
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
Reconstitution Instructions: Reconstitute in sterile dHO not less than 100 g/ml.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Amino acid sequence: N/A
