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Product Description
PECAM is transmembrane glycoprotein that belongs to the Ig-related superfamily of adhesion molecules. It is highly expressed at endothelial cell junctions, and also expressed in platelets and in most leukocyte sub-types. The primary function of PECAM-1 is the mediation of leukocyte-endothelial cell adhesion and signal transduction. PECAM-1 has been implicated in the pathogenesis of various inflammation related disorders, including thrombosis, multiple sclerosis (MS), and rheumatoid arthritis. The human PECAM-1 gene codes for a 738 amino acid transmembrane glycoprotein containing a 118 amino acid cytoplasmic domain, a 19 amino acid transmembrane domain, and a 574 amino acid extracellular domain. Recombinant human PECAM-1 is a 572 amino acid glycoprotein comprising the extracellular domain of PECAM-1. Monomeric glycosylated PECAM-1 migrates at an apparent molecular weight of approximately 80.0-95.0 kDa by SDS-PAGE analysis under reducing conditions.
Biovision | 7184 | Human CellExp PECAM-1 Human Recombinant DataSheet
Biomolecule/Target: PECAM1
Synonyms: Platelet endothelial cell adhesion molecule, CD31 antigen, EndoCAM
Alternates names: GHR, GHBP, GH receptor, Somatotropin receptor, Serum-binding protein
Taglines: Mediates leukocyte-endothelial cell adhesion and signal transduction
NCBI Gene ID #: 2690
NCBI Gene Symbol: GHR
Gene Source: Human
Accession #: P10912
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: HPLC
Endotoxin Level: < 0.1 ng/g of protein (<1EU/g).
Activity (Specifications/test method): N/A
Biological activity: GHBP is fully biologically active as evidenced by its ability of forming 2:1 complex with HGH.
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 30.3 kDa (19-256 aa + N-terminal poly-his tag)
Concentration: N/A
Appearance: Lyophilized powder
Physical form description: Sterile filtered through a 0.2 micron filter. Lyophilized from 10 mM Sodium phosphate, pH 7.5
Reconstitution Instructions: Reconstitute in sterile dHO not less than 100 g/ml. This solution can then be diluted into other aqueous buffers
Amino acid sequence: N/A
