Product Description
Progranulin (PGRN), also called proepithelin and PC cell-derived growth factor, is a single precursor protein of granulins which are a family of secreted, glycosylated peptides. It is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of fronto-temporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimers Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
Biovision | 4737 | Human CellExp Progranulin untagged Human Recombinant DataSheet
Biomolecule/Target: N/A
Synonyms: Recombinant Human Progranulin (Untagged)
Alternates names: GHR, GHBP, GH receptor, Somatotropin receptor, Serum-binding protein
Taglines: Regulator of cell growth, wound healing, and inflammation linked to tumorigenesis
NCBI Gene ID #: 2690
NCBI Gene Symbol: GHR
Gene Source: Human
Accession #: P10912
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: <0.1 EU/µg purified protein
Activity (Specifications/test method): N/A
Biological activity: GHBP is fully biologically active as evidenced by its ability of forming 2:1 complex with HGH.
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 30.3 kDa (19-256 aa + N-terminal poly-his tag)
Concentration: 1 mg/ml
Appearance: Lyophilized protein
Physical form description: Lyophilized from PBS, pH 7.4
Reconstitution Instructions: Reconstitute in sterile dHO not less than 100 g/ml. This solution can then be diluted into other aqueous buffers
Amino acid sequence: N/A