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Product Description
Retinol binding protein 4 (RBP4; RBP) is a 21 kDa secreted protein, a member of the lipocalin family and is known as the primary transporter of retinol (vitamin A) to tissues. A recent report revealed RBP4 as an adipokine linking glucose transporter 4 (GLUT4) suppression in adipose tissue to insulin. Elevated human and mouse serum RBP4 levels are associated with insulin resistance and its severity, obesity, and certain components of metabolic syndrome. Furthermore, human serum RBP4 levels are closely related to renal function.
Biovision | 7563 | Human CellExp RBP4 human recombinant DataSheet
Biomolecule/Target: RBP4
Synonyms: Retinol Binding Protein 4, Plasma retinol-binding protein, PRBP, RBP
Alternates names: Interleukin 31, IL31, IL-31
Taglines: The primary transporter of retinol (vitamin A) to tissues and an adipokine linking GLUT4 suppression in adipose tissue to insulin
NCBI Gene ID #: 386653
NCBI Gene Symbol: IL31
Gene Source: Human
Accession #: Q6EBC2
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: <0.1 EU/g by LAL method
Activity (Specifications/test method): N/A
Biological activity: The ED50 was determined by its ability to activate STAT following receptor ligand interaction and found to be <5 ng/ml, corresponding to a specific activity of 200,000 units.
Results: <5 ng/ml
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 15.8 kDa
Concentration: N/A
Appearance: Liquid
Physical form description: 0.5 mg/ml of 0.2 m-filtered solution in PBS, pH 7.2.
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile HO to a concentration 100 µg/ml. This solution can then be diluted into other aqueous buffers.
Amino acid sequence: SHTLPVRLLRPSDDVQKIVEELQSLSKMLLKDVEEEKGVLVSQNYTLPCLSPDAQPPNNIHSPAIRAYLKTIRQLDNKSVIDEIIEHLDKLIFQDAPETNISVPTDTHECKRFILTISQQFSECMDLALK SLTSGAQQATT
