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Product Description
Human sDLL4 comprises the extracellular signaling domain of DLL, a member of a structurally-related family of single-pass type I trans-membrane proteins that serve as ligands for Notch receptors. DLL4 functions to specifically activate the Notch-1 and Notch-4 receptors. The Notch signaling pathway regulates endothelial-cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. Targeted deletion of the DLL4 gene in mice resulted in severe vascular defects and death before birth. Up-regulation of DLL4 expression has been implicated in the vascular development of certain tumors. Recombinant human sDLL4 is a 54.3 kDa glycoprotein containing 498 amino-acid residues.
Biovision | 7134 | Human CellExp sDLL-4 Human Recombinant DataSheet
Biomolecule/Target: sDLL-4
Synonyms: Delta-like protein 4; Drosophila Delta homolog 4
Alternates names: PRL-R, Prolactin receptor, Lactogen receptor, Prlr, PRL, luteotropic hormone, LTH, PRLR, PRL-R, PRL R
Taglines: Activates the Notch-1 and Notch-2 receptors
NCBI Gene ID #: 24684
NCBI Gene Symbol: Prlr
Gene Source: Rat
Accession #: P05710
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 97%
Assay: SDS-PAGE
Purity: N/A
Assay #2: HPLC
Endotoxin Level: < 0.1 ng/g of protein (<1EU/g).
Activity (Specifications/test method): N/A
Biological activity: Determined by the dose-dependent inhibition of Prolactin stimulated proliferation of Nb2 cells and by high affinity binding of ovine Prolactin and other lactogenic hormones.
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 24.12 kDa
Concentration: N/A
Appearance: Lyophilized powder
Physical form description: Sterile filtered through a 0.2 micron filter. Lyophilized from 1X PBS, pH 7.5.
Reconstitution Instructions: Reconstitute in sterile dHO to a concentration of 0.1 -1 mg/ml and let the lyophilized pellet dissolve completely. This solution can then be diluted into other aqueous buffers
Amino acid sequence: N/A
