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Product Description
The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-4 (T cell; immunoglobulin; Mucin-4), also known as SMUCKLER, is a 60 kDa member of the TIM family of immune regulating proteins. TIM-4 is exclusively expressed on antigen-presenting cells, where it mediates phagocytosis of apoptotic cells and plays an important role in maintaining tolerance. TIM-4 binds specifically to TIM-1 which is also the cellular receptor for the hepatitis A virus, and has been implicated in the development of asthma. Among hematopoietic cells, TIM-1 is expressed on activated B and T cells, preferentially in the Th2 subset of CD4+ T cells. The interaction of TIM-4 with TIM-1 induces costimulatory and hyperproliferative signals in T cells
Biovision | P1361 | Human CellExp Tim-4 Fc-Tag Human Recombinant DataSheet
Biomolecule/Target: Tim-4
Synonyms: TIM4; TIMD4; T Cell Immunoglobulin and Mucin Domain-containing Protein 4; T Cell Membrane Protein 4
Alternates names: YFP, Yellow Fluorescent Protein
Taglines: Involved in regulating T-cell proliferation and lymphotoxin signaling.
NCBI Gene ID #:
NCBI Gene Symbol:
Gene Source:
Accession #:
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 97%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: <5 EU/g by LAL method
Activity (Specifications/test method): N/A
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 26.4 kDa
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from 0.2 m-filtered solution in PBS
Reconstitution Instructions: Reconstitute with dHO to 1 mg/ml
Amino acid sequence: N/A
