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Product Description
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) also known as TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2), Death receptor 5 (DR5), CD262, KILLER, is a member of the TNF-receptor superfamily, and contains an intracellular death domain. TNFRSF10B / DR-5 is widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines. TRAILR2 / CD262 / DR5 is the receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD (a death domain containing adaptor protein) of TRAIL-R2 / TNFRSF10B recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. CD262 / DR5 Promotes the activation of NF-kappa-B. DR5 is essential for ER stress-induced apoptosis and is regulated by p53/TP53.
Biovision | 7448 | Human CellExp TNFRSF10B /TRAILR2 human recombinant DataSheet
Biomolecule/Target: TNFRSF10B /TRAILR2
Synonyms: TNFRSF10B, TRAILR2, TRAIL-R2, CD262, DR5, KILLER, TRICK2, ZTNFR9, TRICKB
Alternates names: KLH, keyhole limpett hemocyanin, hemocyanin, Megathura crenulata hemocyanin
Taglines: A receptor for the cytotoxic ligand TNFSF10/TRAIL
NCBI Gene ID #: N/A
NCBI Gene Symbol: KLH
Gene Source: Megathura crenulata
Accession #: N/A
Recombinant: Yes
Source: Megathura crenulata, Giant keyhole limpet
Purity by SDS-PAGEs: 95%
Assay: MPLC-SEC
Purity: N/A
Assay #2: N/A
Endotoxin Level: <1 EU/g by LAL method
Activity (Specifications/test method): N/A
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 350 and 390 kDa (Two main characteristic bands co-migrating with ferritin)
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Reconstitution Instructions: N/A
Amino acid sequence: N/A
