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Product Description
Aldo-keto reductase family 1 member C3 in humans is encoded by the AKR1C3 gene. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha, 11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation.
Biovision | 6337 | Human Recombinant AKR1C3 DataSheet
Biomolecule/Target: N/A
Synonyms: Human Recombinant AKR1C3
Alternates names: Peptidyl-prolyl cis-trans isomerase-like 3 isoform PPIL3b, CYPJ.
Taglines: Involved in in the detoxification of aldehydes and ketones
NCBI Gene ID #: 53938
NCBI Gene Symbol: PPIL3
Gene Source: Human
Accession #: Q9H2H8
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 90%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: < 1.0 EU per 1 g of protein (determined by LAL method).
Activity (Specifications/test method): N/A
Biological activity: Specific activity is > 280 nmoles/min/mg
Results:
Binding Capacity: N/A
Unit Definition: One unit is the amount of enzyme that reduces 1.0 µmole of NADP+ to NADPH per min. at pH 7.4 at 37°C.
Molecular Weight: 20.3 kDa
Concentration: 1 mg/ml
Appearance: Liquid
Physical form description: 1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol.
Reconstitution Instructions: N/A
Amino acid sequence: MGSSHHHHHH SSGLVPRGSH MSVTLHTDVG DIKIEVFCER TPKTCENFLA LCASNYYNGC IFHRNIKGFM VQTGDPTGTG RGGNSIWGKK FEDEYSEYLK HNVRGVVSMA NNGPNTNGSQ FFITYGKQPH LDMKYTVFGK VIDGLETLDE LEKLPVNEKT YRPLNDVHIK DITIHANPFA Q
