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Product Description
Alpha-enolase, also known as Enolase 1, is one of three enolase isoenzymes and a glycolytic enzyme expressed in most tissues. This protein plays a key role in anaerobic metabolism under hypoxic conditions and may act as a cell surface plasminogen receptor during tissue invasion. Abnormal expression of alpha-enolase is associated with tumor progression in some cases of breast and lung cancer. It also has been identified as an auto antigen associated with Hashimoto's encephalopathy and severe asthma.
Biovision | 6363 | Human Recombinant Alpha-Enolase DataSheet
Biomolecule/Target: ENO1
Synonyms: Human Recombinant Alpha-Enolase
Alternates names: Peptidyl-prolyl cis-trans isomerase-like 4, HDCME13P, Rotamase PPIL4, Cyclophilin-like protein PPIL4.
Taglines: A metalloenzyme responsible for conversion of 2-PG to PEP
NCBI Gene ID #: 85313
NCBI Gene Symbol: PPIL4
Gene Source: Human
Accession #: Q8WUA2
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 85%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): N/A
Biological activity: Specific activity is > 190 nmoles/min/mg
Results:
Binding Capacity: N/A
Unit Definition: One unit is the amount of enzyme that will generate 1.0 nmole of H2O2 per minute at pH 7.2 and 25 C.
Molecular Weight: 59.4 kDa
Concentration: 1 mg/ml
Appearance: Liquid
Physical form description: In 50 mM Tris, 150 mM NaCl, 20 mM MgCl2 and 20% Glycerol
Reconstitution Instructions: N/A
Amino acid sequence: MGSSHHHHHH SSGLVPRGSH MAVLLETTLG DVVIDLYTEE RPRACLNFLK LCKIKYYNYC LIHNVQRDFI IQTGDPTGTG RGGESIFGQL YGDQASFFEA EKVPRIKHKK KGTVSMVNNG SDQHGSQFLI TTGENLDYLD GVHTVFGEVT EGMDIIKKIN ETFVDKDFVP YQDIRINHTV ILDDPFDDPP DLLIPDRSPE PTREQLDSGR IGADEEIDDF KGRSAEEVEE IKAEKEAKTQ AILLEMVGDL PDADIKPPEN VLFVCKLNPV TTDEDLEIIF SRFGPIRSCE VIRDWKTGES LCYAFIEFEK EEDCEKAFFK MDNVLIDDRR IHVDFSQSVA KVKWKGKGGK YTKSDFKEYE KEQDKPPNLV LKDKVKPKQD TKYDLILDEQ AEDSKSSHSH TSKKHKKKTH HCSEEKEDED YMPIKNTNQD IYREMGFGHY EEEESCWEKQ KSEKRDRTQN RSRSRSRERD GHYSNSHKSK YQTDLYERER SKKRDRSRSP KKSKDKEKSK YR
