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Product Description
Cyclophilin D is a member of peptidyl-propyl cis-trans isomerase (PPIase) family, which catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerates the folding of proteins and thus their formation. Cyclophilin D is also a mitochondrial matrix protein, which plays a decisive role in mitochondrial permeability transition. It can bind to the immunosuppressant cyclosporine A and its overexpression suppresses the apoptosis in cancer cells.
Biovision | 6312 | Human Recombinant Cyclophilin D DataSheet
Biomolecule/Target: N/A
Synonyms: Human Recombinant Cyclophilin D
Alternates names: Peptidylprolyl isomerase D, PPID, CYPD, CYP-40
Taglines: An immunophilin family protein catalyzing the isomerization of peptide bonds
NCBI Gene ID #: 332
NCBI Gene Symbol: BIRC5
Gene Source: Human
Accession #: O15392
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 90%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): N/A
Biological activity: Specific activity is > 210 nmoles/min/mg
Results: N/A
Binding Capacity: N/A
Unit Definition: Specific activity is defined as the amount of enzyme that cleaves 1 µmole of Suc-AAFP-pNA per minute at 25°C in Tris HCl pH 8.0 using chymotrypsin.
Molecular Weight: 42.9 kDa
Concentration: 1 mg/ml
Appearance: Liquid
Physical form description: 1 mg/ml solution in PBS (pH 7.4) containing 10% glycerol.
Reconstitution Instructions: N/A
Amino acid sequence: MGSSHHHHHH SSGLVPRGSH MSHPSPQAKP SNPSNPRVFF DVDIGGERVG RIVLELFADI VPKTAENFRA LCTGEKGIGH TTGKPLHFKG CPFHRIIKKF MIQGGDFSNQ NGTGGESIYG EKFEDENFHY KHDREGLLSM ANAGRNTNGS QFFITTVPTP HLDGKHVVFG QVIKGIGVAR ILENVEVKGE KPAKLCVIAE CGelKEGDDG GIFPKDGSGD SHPDFPEDAD IDLKDVDKIL LITEDLKNIG NTFFKSQNWE MAIKKYAEVL
