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Product Description
Human IGF-BP5 is a 28.6 kDa cysteine-rich secreted protein produced by Vascular smooth muscle cells. It is the major IGF-binding protein present in bone tissue and helps potentiate the action of IGF-I on smooth muscle cells, fibroblasts or osteoblasts. Studies show that IGF-BP5 acts as a growth inhibitor and pro-apoptotic agent in breast cancer cells. IGF-BP5 overexpressing mice show an increase in neonatal mortality, reduced female fertility, whole body growth inhibition, and retarded muscle development. Recombinant human IGF-BP5 is a 28.6 kDa protein consisting of 253 amino acid residues.
Biovision | 4723 | IGF-BP5 human recombinant DataSheet
Biomolecule/Target: N/A
Synonyms: Insulin-like Growth Factor-Binding Protein5
Alternates names: Ubiquitin carboxyl-terminal hydrolase isozyme L5, UCH37
Taglines: A protein which binds and prolongs the half-life of the IGFs
NCBI Gene ID #: 51377
NCBI Gene Symbol: UCHL5
Gene Source: Human
Accession #: Q9Y5K5
Recombinant: Yes
Source: E. Coli
Purity by SDS-PAGEs: 90%
Assay: SDS-PAGE
Purity: 98%
Assay #2: HPLC
Endotoxin Level: <0.1 ng/g
Activity (Specifications/test method): N/A
Biological activity: Specific activity: >500 pmole/min/µg. Measured by the hydrolysis of Ubiquitin-AMC at pH 8.0, at 37°C.
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 39.7 kDa (349 aa, 1-329 aa + NT His Tag)
Concentration: N/A
Appearance: Lyophilized protein
Physical form description: Sterile filtered and lyophilized from 10 mM Sodium Citrate solution, pH 3.0.
Reconstitution Instructions: N/A
Amino acid sequence: MGSSHHHHHH SSGLVPRGSH MTGNAGEWCL MESDPGVFTE LIKGFGCRGA QVEEIWSLEP ENFEKLKPVH GLIFLFKWQP GEEPAGSVVQ DSRLDTIFFA KQVINNACAT QAIVSVLLNC THQDVHLGET LSEFKEFSQS FDAAMKGLAL SNSDVIRQVH NSFARQQMFE FDTKTSAKEE DAFHFVSYVP VNGRLYELDG LREGPIDLGA CNQDDWISAV RPVIEKRIQK YSEGEIRFNL MAIVSDRKMI YEQKIAELQR QLAEEEPMDT DQGNSMLSAI QSEVAKNQML IEEEVQKLKR YKIENIRRKH NYLPFIMELL KTLAEHQQLI PLVEKAKEKQ NAKKAQETK
