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Product Description
IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant murine IL-6 is a 21.7 kDa protein containing 187 amino acid residues.
Biovision | 4144 | IL-6 murine recombinant DataSheet
Biomolecule/Target: IL-6
Synonyms: IFN-b2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2, IL-6, Interleukin HP-1, B-cell hybridoma growth factor,
Alternates names: BMP-2, BMP2A
Taglines: An important mediator of acute phase response
NCBI Gene ID #: 650
NCBI Gene Symbol: BMP2
Gene Source: Human
Accession #: P12643
Recombinant: Yes
Source: Human 293 cell expressed
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: 98%
Assay #2: HPLC
Endotoxin Level: <0.1 ng/g
Activity (Specifications/test method): N/A
Biological activity: ED is typically 20 to 100 ng/mL. The specific activity was determined by the dose dependent induction of alkaline phosphatase production in the ATDC-5 cell line (Mouse chondrogenic cell line).
Results: 20 to 100 ng/ml
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 30 to 38 kDa, homodimer, glycosylated.
Concentration: N/A
Appearance: Lyophilized protein
Physical form description: Lyophilized with no additives.
Reconstitution Instructions: Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.
Amino acid sequence: N/A
