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Product Description
Interleukin-17AF (IL-17AF) is a member of the IL-17 family of proteins produced by a subset of T cells, called Th17, following stimulation with IL-23. Since IL-17AF is thought to signal through the IL-17R receptor, its biological function is similar to that of IL-17A in that it induces the production of a variety of chemokines, in addition to airway neutrophilia. In regard to these functions, IL-17AF has less activity than the IL-17A homodimer but, greater activity than the IL-17F homodimer. Human and rat IL-17AF both show activity on mouse cells. Recombinant rat IL-17AF is a non-glycosylated, disulfide-linked heterodimer. It is comprised of one monomeric subunit each of IL-17A and IL-17F, having a total of 269 amino acids and a molecular weight of 30.7 kDa.
Biovision | 7587 | IL17 A/F Rat Recombinant DataSheet
Biomolecule/Target: IL17 A/F
Synonyms: Interleukin 17 A/F, IL-17A, IL-17F, Interleukin 17A, Interleukin 17F
Alternates names: Lactoylglutathione lyase, Glx 1, GLO-1 Methylglyoxalase, Aldoketomutase
Taglines: Induces the production of a variety of chemokines
NCBI Gene ID #: 2739
NCBI Gene Symbol: GLO1
Gene Source: Human
Accession #: Q04760
Recombinant: Yes
Source: E. Coli
Purity by SDS-PAGEs: 90%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: Measured by kinetic LAL analysis and is typically 1 EU/g protein
Activity (Specifications/test method): N/A
Biological activity: Specific activity: >0.4 units/mg.
Results: >0.4 units/mg
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 20.7 kDa (184 aa, 1-184 aa)
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized without any additives.
Reconstitution Instructions: N/A
Amino acid sequence: MAEPQPPSGG LTDEAALSCC SDADPSTKDF LLQQTMLRVK DPKKSLDFYT RVLGMTLIQK CDFPIMKFSL YFLAYEDKND IPKEKDEKIA WALSRKATLE LTHNWGTEDD ETQSYHNGNS DPRGFGHIGI AVPDVYSACK RFEELGVKFV KKPDDGKMKG LAFIQDPDGY WIEILNPNKM ATLM
